AUTHOR=Bermejo-Jambrina Marta , Eder Julia , Helgers Leanne C. , Hertoghs Nina , Nijmeijer Bernadien M. , Stunnenberg Melissa , Geijtenbeek Teunis B. H. 

TITLE=C-Type Lectin Receptors in Antiviral Immunity and Viral Escape

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00590

DOI=10.3389/fimmu.2018.00590

ISSN=1664-3224

ABSTRACT=<p>C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral infections as they efficiently interact with viruses. However, it has become clear that deadly viruses subvert the function of CLRs to escape antiviral immunity and promote infection. In particular, viruses target CLRs to suppress or modulate type I interferons that play a central role in the innate and adaptive defense against viruses. In this review, we discuss the function of CLRs in binding to enveloped viruses like HIV-1 and Dengue virus, and how uptake and signaling cascades have decisive effects on the outcome of infection.</p>