AUTHOR=Guri Yakir , Nordmann Thierry M. , Roszik Jason 

TITLE=mTOR at the Transmitting and Receiving Ends in Tumor Immunity

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00578

DOI=10.3389/fimmu.2018.00578

ISSN=1664-3224

ABSTRACT=<p>Cancer is a complex disease and a leading cause of death worldwide. Immunity is critical for cancer control. Cancer cells exhibit high mutational rates and therefore altered self or neo-antigens, eliciting an immune response to promote tumor eradication. Failure to mount a proper immune response leads to cancer progression. mTOR signaling controls cellular metabolism, immune cell differentiation, and effector function. Deregulated mTOR signaling in cancer cells modulates the tumor microenvironment, thereby affecting tumor immunity and possibly promoting carcinogenesis.</p>