AUTHOR=Lê-Bury Gabrielle , Niedergang Florence 

TITLE=Defective Phagocytic Properties of HIV-Infected Macrophages: How Might They Be Implicated in the Development of Invasive Salmonella Typhimurium?

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00531

DOI=10.3389/fimmu.2018.00531

ISSN=1664-3224

ABSTRACT=<p>Human immunodeficiency virus type 1 (HIV-1) infects and kills T cells, profoundly damaging the host-specific immune response. The virus also integrates into memory T cells and long-lived macrophages, establishing chronic infections. HIV-1 infection impairs the functions of macrophages both <italic>in vivo</italic> and <italic>in vitro</italic>, which contributes to the development of opportunistic diseases. Non-typhoidal <italic>Salmonella enterica</italic> serovar Typhimurium has been identified as the most common cause of bacterial bloodstream infections in HIV-infected adults. In this review, we report how the functions of macrophages are impaired post HIV infection; introduce what makes invasive <italic>Salmonella</italic> Typhimurium specific for its pathogenesis; and finally, we discuss why these bacteria may be particularly adapted to the HIV-infected host.</p>