AUTHOR=Ribeyre Camille , Carlini Federico , René Céline , Jordier François , Picard Christophe , Chiaroni Jacques , Abi-Rached Laurent , Gouret Philippe , Marin Grégory , Molinari Nicolas , Chanez Pascal , Paganini Julien , Gras Delphine , Di Cristofaro Julie TITLE=HLA-G Haplotypes Are Differentially Associated with Asthmatic Features JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00278 DOI=10.3389/fimmu.2018.00278 ISSN=1664-3224 ABSTRACT=
Human leukocyte antigen (HLA)-G, a HLA class Ib molecule, interacts with receptors on lymphocytes such as T cells, B cells, and natural killer cells to influence immune responses. Unlike classical HLA molecules, HLA-G expression is not found on all somatic cells, but restricted to tissue sites, including human bronchial epithelium cells (HBEC). Individual variation in HLA-G expression is linked to its genetic polymorphism and has been associated with many pathological situations such as asthma, which is characterized by epithelium abnormalities and inflammatory cell activation. Studies reported both higher and equivalent soluble HLA-G (sHLA-G) expression in different cohorts of asthmatic patients. In particular, we recently described impaired local expression of HLA-G and abnormal profiles for alternatively spliced isoforms in HBEC from asthmatic patients. sHLA-G dosage is challenging because of its many levels of polymorphism (dimerization, association with β2-microglobulin, and alternative splicing), thus many clinical studies focused on