AUTHOR=Wagener Matthew , Hoving J. Claire , Ndlovu Hlumani , Marakalala Mohlopheni J. 

TITLE=Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00225

DOI=10.3389/fimmu.2018.00225

ISSN=1664-3224

ABSTRACT=<p>One of the first steps toward mounting an effective immune response to <italic>Mycobacterium tuberculosis</italic> (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins, including spleen tyrosine kinase, protein kinase C-delta, and caspase recruitment domain family member 9, some of which have been shown to influence host immune response to TB infection. Here, we review the role of Dectin-1 signaling pathway in anti-mycobacterial immunity and discuss its contribution in the control of Mtb infection, and potential applications in TB vaccine adjuvanticity.</p>