AUTHOR=Cook Dana P. , Gysemans Conny , Mathieu Chantal 

TITLE=Lactococcus lactis As a Versatile Vehicle for Tolerogenic Immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01961

DOI=10.3389/fimmu.2017.01961

ISSN=1664-3224

ABSTRACT=<p>Genetically modified <italic>Lactococcus lactis</italic> bacteria have been engineered as a tool to deliver bioactive proteins to mucosal tissues as a means to exert both local and systemic effects. They have an excellent safety profile, the result of years of human consumption in the food industry, as well as a lack of toxicity and immunogenicity. Also, containment strategies have been developed to promote further application as clinical protein-based therapeutics. Here, we review technological advancements made to enhanced the potential of <italic>L. lactis</italic> as live biofactories and discuss some examples of tolerogenic immunotherapies mediated by mucosal drug delivery <italic>via L. lactis</italic>. Additionally, we highlight their use to induce mucosal tolerance by targeted autoantigen delivery to the intestine as an approach to reverse autoimmune type 1 diabetes.</p>