AUTHOR=Marsh Rebecca A. 

TITLE=Epstein–Barr Virus and Hemophagocytic Lymphohistiocytosis

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01902

DOI=10.3389/fimmu.2017.01902

ISSN=1664-3224

ABSTRACT=<p>Epstein–Barr virus (EBV) is a ubiquitous virus that infects nearly all people worldwide without serious sequela. However, for patients who have genetic diseases which predispose them to the development of hemophagocytic lymphohistiocytosis (HLH), EBV infection is a life-threatening problem. As a part of a themed collection of articles on EBV infection and human primary immune deficiencies, we will review key concepts related to the understanding and treatment of HLH.</p>