AUTHOR=Uppendahl Locke D. , Dahl Carly M. , Miller Jeffrey S. , Felices Martin , Geller Melissa A. 

TITLE=Natural Killer Cell-Based Immunotherapy in Gynecologic Malignancy: A Review

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01825

DOI=10.3389/fimmu.2017.01825

ISSN=1664-3224

ABSTRACT=<p>Harnessing the immune system has proven an effective therapy in treating malignancies. Since the discovery of natural killer (NK) cells, strategies aimed to manipulate and augment their effector function against cancer have been the subject of intense research. Recent progress in the immunobiology of NK cells has led to the development of promising therapeutic approaches. In this review, we will focus on the recent advances in NK cell immunobiology and the clinical application of NK cell immunotherapy in ovarian, cervical, and uterine cancer.</p>