AUTHOR=Núñez David , Comas Laura , Lanuza Pilar M. , Sánchez-Martinez Diego , Pérez-Hernández Marta , Catalán Elena , Domingo María Pilar , Velázquez-Campoy Adrián , Pardo Julián , Gálvez Eva M. TITLE=A Functional Analysis on the Interspecies Interaction between Mouse LFA-1 and Human Intercellular Adhesion Molecule-1 at the Cell Level JOURNAL=Frontiers in Immunology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01817 DOI=10.3389/fimmu.2017.01817 ISSN=1664-3224 ABSTRACT=
The interaction between intercellular adhesion molecules (ICAM) and the integrin leukocyte function-associated antigen-1 (LFA-1) is crucial for the regulation of several physiological and pathophysiological processes like cell-mediated elimination of tumor or virus infected cells, cancer metastasis, or inflammatory and autoimmune processes. Using purified proteins it was reported a species restriction for the interaction of ICAM-1 and LFA-1, being mouse ICAM-1 able to interact with human LFA-1 but not human ICAM-1 with mouse LFA-1. However,