AUTHOR=Zhang Sai-Long , Wang Shu-Na , Miao Chao-Yu 

TITLE=Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01674

DOI=10.3389/fimmu.2017.01674

ISSN=1664-3224

ABSTRACT=<p>Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with chronic and recurrent characteristics caused by multiple reasons. Although the pathogenic factors have not been clarified yet, recent studies have demonstrated that intestinal microbiota plays a major role in UC, especially in the immune system. This review focuses on the description of several major microbiota communities that affect UC and their interactions with the host. In this review, eight kinds of microbiota that are highly related to IBD, including <italic>Faecalibacterium prausnitzii, Clostridium</italic> clusters IV and XIVa, <italic>Bacteroides, Roseburia</italic> species, <italic>Eubacterium rectale, Escherichia coli, Fusobacterium</italic>, and <italic>Candida albicans</italic> are demonstrated on the changes in amount and roles in the onset and progression of IBD. In addition, potential therapeutic targets for UC involved in the regulation of microbiota, including NLRPs, vitamin D receptor as well as secreted proteins, are discussed in this review.</p>