AUTHOR=Steele Edward J. 

TITLE=Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01611

DOI=10.3389/fimmu.2017.01611

ISSN=1664-3224

ABSTRACT=<p>The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet’s Clonal Selection Theory, the evidence is briefly reviewed and updated.</p>