AUTHOR=Symowski Cornelia , Voehringer David 

TITLE=Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01422

DOI=10.3389/fimmu.2017.01422

ISSN=1664-3224

ABSTRACT=<p>Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system. Work over the past few years indicates that ILC2s play a central role in regulating type 2 immune responses against allergens and helminths. ILC2s can interact with a variety of cells types of the innate and adaptive immune system by cell–cell contacts or by communication <italic>via</italic> soluble factors. In this review, we provide an overview about recent advances in our understanding how ILC2s orchestrate type 2 immune responses with focus on direct interactions between ILC2s and other cells of the immune system.</p>