AUTHOR=Shehata Hesham M. , Murphy Andrew J. , Lee Man kit Sam , Gardiner Clair M. , Crowe Suzanne M. , Sanjabi Shomyseh , Finlay David K. , Palmer Clovis Steve 

TITLE=Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01311

DOI=10.3389/fimmu.2017.01311

ISSN=1664-3224

ABSTRACT=<p>The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.</p>