AUTHOR=Selenius Jannica S. , Martelius Timi , Pikkarainen Sampsa , Siitonen Sanna , Mattila Eero , Pietikäinen Risto , Suomalainen Pekka , Aalto Arja H. , Saarela Janna , Einarsdottir Elisabet , Järvinen Asko , Färkkilä Martti , Kere Juha , Seppänen Mikko TITLE=Unexpectedly High Prevalence of Common Variable Immunodeficiency in Finland JOURNAL=Frontiers in Immunology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01190 DOI=10.3389/fimmu.2017.01190 ISSN=1664-3224 ABSTRACT=Background

Common variable immunodeficiency (CVID) is the most common primary immunodeficiency. Prevalence varies greatly between countries and studies. Most diagnostic criteria include hypogammaglobulinemia and impaired vaccine response.

Aim

To evaluate the minimum prevalence as well as the clinical and immunological phenotypes of CVID in Southern Finland.

Methods

We performed a cross-sectional study to assess all adult CVID patients followed up in three hospital districts in Southern and South-Eastern Finland between April 2007 and August 2015. CVID diagnosis was based, with a minor modification, on the ESID/PAGID criteria for primary CVID. Antipolysaccharide responses to Pneumovax® were defined as impaired only if 50% or more of the serotypes did not reach a level of 0.35 µg/mL after vaccination. We further characterized the patients’ B cell phenotypes and complications associated with CVID.

Results

In total, 9 patients were excluded due to potential secondary causes before diagnosis. ESID/PAGID criteria were met by 132 patients (males 52%), of whom, 106 had “probable” and 26 “possible CVID.” Based on the population statistics in the three hospital districts, the minimum adult prevalence per 100,000 inhabitants in Finland for all CVID (“probable CVID,” respectively) patients was 6.9 (5.5). In the highest prevalence district (Helsinki and Uusimaa), the prevalence was 7.7 (6.1). CVID patients suffer from frequent complications. Ten patients died during follow-up. Of probable CVID patients, 73% had more than one clinical phenotype. Intriguingly, gradual B cell loss from peripheral blood during follow-up was seen in as many as 16% of “probable CVID” patients. Patients with possible CVID displayed somewhat milder clinical and laboratory phenotypes than probable CVID patients. We also confirm that large granular lymphocyte lymphoproliferation is a CVID-associated complication.

Conclusion

The prevalence of CVID in Finland appears the highest recorded, likely reflecting the genetic isolation and potential founder effects in the Finnish population. Studies to discover potential gene variants responsible for the high prevalence in Finland thus seem warranted. Increased awareness of CVID among physicians would likely lead to earlier diagnosis and improved quality of care.