AUTHOR=Leiding Jennifer W. 

TITLE=Neutrophil Evolution and Their Diseases in Humans

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01009

DOI=10.3389/fimmu.2017.01009

ISSN=1664-3224

ABSTRACT=<p>Granulocytes have been preserved and have evolved across species, developing into cells that provide one of the first lines of host defense against pathogens. In humans, neutrophils are involved in early recognition and killing of infectious pathogens. Disruption in neutrophil production, emigration, chemotaxis, and function cause a spectrum of primary immune defects characterized by host susceptibility to invasive infections.</p>