AUTHOR=Pereira Leonn Mendes Soares , Gomes Samara Tatielle Monteiro , Ishak Ricardo , Vallinoto Antonio Carlos Rosário 

TITLE=Regulatory T Cell and Forkhead Box Protein 3 as Modulators of Immune Homeostasis

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00605

DOI=10.3389/fimmu.2017.00605

ISSN=1664-3224

ABSTRACT=<p>The transcription factor forkhead box protein 3 (FOXP3) is an essential molecular marker of regulatory T cell (Treg) development in different microenvironments. Tregs are cells specialized in the suppression of inadequate immune responses and the maintenance of homeostatic tolerance. Studies have addressed and elucidated the role played by FOXP3 and Treg in countless autoimmune and infectious diseases as well as in more specific cases, such as cancer. Within this context, the present article reviews aspects of the immunoregulatory profile of FOXP3 and Treg in the management of immune homeostasis, including issues relating to pathology as well as immune tolerance.</p>