AUTHOR=Mancheño-Corvo Pablo , Lopez-Santalla Mercedes , Menta Ramon , DelaRosa Olga , Mulero Francisca , del Rio Borja , Ramirez Cristina , Büscher Dirk , Bueren Juan A. , Lopez-Belmonte Juan , Dalemans Wilfried , Garin Marina I. , Lombardo Eleuterio TITLE=Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis JOURNAL=Frontiers in Immunology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00462 DOI=10.3389/fimmu.2017.00462 ISSN=1664-3224 ABSTRACT=
Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues associated with the inflammatory site where functional MSC-induced immune cells with a regulatory phenotype were increased mediating the immunomodulatory effects of MSCs. These results suggest that homing of MSCs to the lymphatic system plays an important role in the mechanism of action of MSCs