AUTHOR=Laurent Paôline , Jolivel Valérie , Manicki Pauline , Chiu Lynn , Contin-Bordes Cécile , Truchetet Marie-Elise , Pradeu Thomas TITLE=Immune-Mediated Repair: A Matter of Plasticity JOURNAL=Frontiers in Immunology VOLUME=8 YEAR=2017 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00454 DOI=10.3389/fimmu.2017.00454 ISSN=1664-3224 ABSTRACT=

Though the immune system is generally defined as a system of defense, it is increasingly recognized that the immune system also plays a crucial role in tissue repair and its potential dysregulations. In this review, we explore how distinct immune cell types are involved in tissue repair and how they interact in a process that is tightly regulated both spatially and temporally. We insist on the concept of immune cell plasticity which, in recent years, has proved fundamental for the success/understanding of the repair process. Overall, the perspective presented here suggests that the immune system plays a central role in the physiological robustness of the organism, and that cell plasticity contributes to the realization of this robustness.