AUTHOR=Wei Jun , Raynor Jana , Nguyen Thanh-Long M. , Chi Hongbo 

TITLE=Nutrient and Metabolic Sensing in T Cell Responses

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00247

DOI=10.3389/fimmu.2017.00247

ISSN=1664-3224

ABSTRACT=<p>T cells play pivotal roles in shaping host immune responses in infectious diseases, autoimmunity, and cancer. The activation of T cells requires immune and growth factor-derived signals. However, alterations in nutrients and metabolic signals tune T cell responses by impinging upon T cell fates and immune functions. In this review, we summarize how key nutrients, including glucose, amino acids, and lipids, and their sensors and transporters shape T cell responses. We also briefly discuss regulation of T cell responses by oxygen and energy sensing mechanisms.</p>