AUTHOR=Stone Brandee L. , Brissette Catherine A. 

TITLE=Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00012

DOI=10.3389/fimmu.2017.00012

ISSN=1664-3224

ABSTRACT=<p>The emerging pathogen, <italic>Borrelia miyamotoi</italic>, is a relapsing fever spirochete vectored by the same species of <italic>Ixodes</italic> ticks that carry the causative agents of Lyme disease in the US, Europe, and Asia. Symptoms caused by infection with <italic>B. miyamotoi</italic> are similar to a relapsing fever infection. However, <italic>B. miyamotoi</italic> has adapted to different vectors and reservoirs, which could result in unique physiology, including immune evasion mechanisms. Lyme <italic>Borrelia</italic> utilize a combination of <italic>Ixodes</italic>-produced inhibitors and native proteins [i.e., factor H-binding proteins (FHBPs)/complement regulator-acquiring surface proteins, p43, BBK32, BGA66, BGA71, CD59-like protein] to inhibit complement, while some relapsing fever spirochetes use C4b-binding protein and likely <italic>Ornithodoros</italic>-produced inhibitors. To evade the humoral response, <italic>Borrelia</italic> utilize antigenic variation of either outer surface proteins (Osps) and the Vmp-like sequences (Vls) system (Lyme borreliae) or variable membrane proteins (Vmps, relapsing fever borreliae). <italic>B. miyamotoi</italic> possesses putative FHBPs and antigenic variation of Vmps has been demonstrated. This review summarizes and compares the common mechanisms utilized by Lyme and relapsing fever spirochetes, as well as the current state of understanding immune evasion by <italic>B. miyamotoi</italic>.</p>