AUTHOR=Bonavita Ornella , Mollica Poeta Valeria , Setten Elisa , Massara Matteo , Bonecchi Raffaella 

TITLE=ACKR2: An Atypical Chemokine Receptor Regulating Lymphatic Biology

JOURNAL=Frontiers in Immunology

VOLUME=7

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00691

DOI=10.3389/fimmu.2016.00691

ISSN=1664-3224

ABSTRACT=<p>The lymphatic system plays an important role in the induction of the immune response by transporting antigens, inflammatory mediators, and leukocytes from peripheral tissues to draining lymph nodes. It is emerging that lymphatic endothelial cells (LECs) are playing an active role in this context <italic>via</italic> the expression of chemokines, inflammatory mediators promoting cell migration, and chemokine receptors. Particularly, LECs express atypical chemokine receptors (ACKRs), which are unable to promote conventional signaling and cell migration while they are involved in the regulation of chemokine availability. Here, we provide a summary of the data on the role of ACKR2 expressed by lymphatics, indicating an essential role for this ACKRs in the regulation of the inflammation and the immune response in different pathological conditions, including infection, allergy, and cancer.</p>