AUTHOR=Xu-yang Zheng , Pei-yu Bian , Chuan-tao Ye , Wei Ye , Hong-wei Ma , Kang Tang , Chun-mei Zhang , Ying-feng Lei , Xin Wei , Ping-zhong Wang , Chang-xing Huang , Xue-fan Bai , Ying Zhang , Zhan-sheng Jia TITLE=Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome JOURNAL=Frontiers in Immunology VOLUME=7 YEAR=2017 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00535 DOI=10.3389/fimmu.2016.00535 ISSN=1664-3224 ABSTRACT=
Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polymorphisms (SNP) rs12252 C allele and CC genotype associated with the disease severity and HTNV load in the plasma of HFRS patients.