AUTHOR=Hong Jung Joo , Chang Kyu-Tae , Villinger Francois 

TITLE=The Dynamics of T and B Cells in Lymph Node during Chronic HIV Infection: TFH and HIV, Unhappy Dance Partners?

JOURNAL=Frontiers in Immunology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00522

DOI=10.3389/fimmu.2016.00522

ISSN=1664-3224

ABSTRACT=<p>Although the dynamics of germinal center (GC) formation, follicular helper T (TFH) cell recruitment to <italic>B cell follicle</italic>s within lymphoid organs, and changes of lymphoid tissue architecture in HIV/SIV infection have been documented, the underlying immunopathology remains unclear. Here, we summarize what is known regarding the kinetics of TFH cells and <italic>GC B cells</italic> during the course of infection as well as the potential immunopathological features associated with structural changes in the lymphoid compartment. This review also explores the implications of cell dynamics in the formation and maintenance of viral reservoirs in hyperplastic follicles of secondary lymphoid organs before and after viral suppressive antiretroviral therapy.</p>