AUTHOR=Chabannon Christian , Mfarrej Bechara , Guia Sophie , Ugolini Sophie , Devillier Raynier , Blaise Didier , Vivier Eric , Calmels Boris TITLE=Manufacturing Natural Killer Cells as Medicinal Products JOURNAL=Frontiers in Immunology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00504 DOI=10.3389/fimmu.2016.00504 ISSN=1664-3224 ABSTRACT=
Natural Killer (NK) cells are innate lymphoid cells (ILC) with cytotoxic and regulatory properties. Their functions are tightly regulated by an array of inhibitory and activating receptors, and their mechanisms of activation strongly differ from antigen recognition in the context of human leukocyte antigen presentation as needed for T-cell activation. NK cells thus offer unique opportunities for new and improved therapeutic manipulation, either