AUTHOR=Gregori Silvia , Passerini Laura , Roncarolo Maria-Grazia 

TITLE=Clinical Outlook for Type-1 and FOXP3+ T Regulatory Cell-Based Therapy

JOURNAL=Frontiers in Immunology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00593

DOI=10.3389/fimmu.2015.00593

ISSN=1664-3224

ABSTRACT=<p>T regulatory cells (Tregs) are subsets of T lymphocytes specialized in modulating antigen-specific immune responses <italic>in vivo</italic>. Hence, Tregs represent an ideal therapeutic tool to control detrimental immune reactions. Based on solid pre-clinical results, investigators started testing the safety and efficacy of Treg-based therapies in humans. Despite promising results, a number of issues remain to be solved. We will discuss the results obtained from clinical trials and the challenges and risks we are facing in the further development of Treg-based therapies.</p>