AUTHOR=Huang Xinfang , Dorta-Estremera Stephanie , Yao Yihong , Shen Nan , Cao Wei 

TITLE=Predominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity

JOURNAL=Frontiers in Immunology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00526

DOI=10.3389/fimmu.2015.00526

ISSN=1664-3224

ABSTRACT=<p>Plasmacytoid dendritic cells (pDCs), which are prominent type I interferon (IFN-I)-producing immune cells, have been extensively implicated in systemic lupus erythematosus (SLE). However, whether they participate critically in lupus pathogenesis remains unknown. Recent studies using various genetic and cell type-specific ablation strategies have demonstrated that pDCs play a pivotal role in the development of autoantibodies and the progression of lupus under diverse experimental conditions. The findings of several investigations highlight a notion that pDCs operate critically at the early stage of lupus development. In particular, pDCs have a profound effect on B-cell activation and humoral autoimmunity <italic>in vivo</italic>. This deeper understanding of the vital role of pDCs in lupus pathogenesis supports the therapeutic targeting of the pDC-IFN-I pathway in SLE.</p>