AUTHOR=Iruretagoyena Mirentxu , Hirigoyen Daniela , Naves Rodrigo , Burgos Paula Isabel 

TITLE=Immune Response Modulation by Vitamin D: Role in Systemic Lupus Erythematosus

JOURNAL=Frontiers in Immunology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00513

DOI=10.3389/fimmu.2015.00513

ISSN=1664-3224

ABSTRACT=<p>Vitamin D plays key roles as a natural immune modulator and has been implicated in the pathophysiology of autoimmune diseases, including systemic lupus erythematosus (SLE). This review presents a summary and analysis of the recent literature regarding immunoregulatory effects of vitamin D as well as its importance in SLE development, clinical severity, and possible effects of supplementation in disease treatment.</p>