AUTHOR=Jurberg Arnon Dias , Vasconcelos-Fontes Larissa , Cotta-de-Almeida Vinícius 

TITLE=A Tale from TGF-β Superfamily for Thymus Ontogeny and Function

JOURNAL=Frontiers in Immunology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00442

DOI=10.3389/fimmu.2015.00442

ISSN=1664-3224

ABSTRACT=<p>Multiple signaling pathways control every aspect of cell behavior, organ formation, and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/bone morphogenetic protein ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.</p>