AUTHOR=Jones William , Bianchi Katiuscia 

TITLE=Aerobic Glycolysis: Beyond Proliferation

JOURNAL=Frontiers in Immunology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00227

DOI=10.3389/fimmu.2015.00227

ISSN=1664-3224

ABSTRACT=<p>Aerobic glycolysis has been generally associated with cancer cell proliferation, but fascinating and novel data show that it is also coupled to a series of further cellular functions. In this <italic>Mini Review</italic>, we will discuss some recent findings to illustrate newly defined roles for this process, in particular in non-malignant cells, supporting the idea that metabolism can be considered as an integral part of cellular signaling. Consequently, metabolism should be regarded as a plastic and highly dynamic determinant of a wide range of cellular specific functions.</p>