AUTHOR=Stoffels Monique , Zaal Ruben , Kok Nina , van der Meer Jos W. M. , Dinarello Charles A. , Simon Anna TITLE=ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions JOURNAL=Frontiers in Immunology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00054 DOI=10.3389/fimmu.2015.00054 ISSN=1664-3224 ABSTRACT=
Interleukin-1β is a potent proinflammatory cytokine, of which processing and secretion are tightly regulated. After exposure to various stimuli, mononuclear phagocytes synthesize the inactive precursor (pro-IL-1β), which is then cleaved intracellularly by caspase-1 and secreted. A widely used method for