AUTHOR=Ruocco Maria Grazia , Chaouat Gérard , Florez Laura , Bensussan Armand , Klatzmann David TITLE=Regulatory T-Cells in Pregnancy: Historical Perspective, State of the Art, and Burning Questions JOURNAL=Frontiers in Immunology VOLUME=5 YEAR=2014 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00389 DOI=10.3389/fimmu.2014.00389 ISSN=1664-3224 ABSTRACT=

In this review, we first revisit the original concept of “suppressor T-cells” in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of “regulatory T-cells” (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal–fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.