AUTHOR=Fehres Cynthia M. , Unger Wendy W. J. , Garcia-Vallejo Juan J. , van Kooyk Yvette 

TITLE=Understanding the Biology of Antigen Cross-Presentation for the Design of Vaccines Against Cancer

JOURNAL=Frontiers in Immunology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00149

DOI=10.3389/fimmu.2014.00149

ISSN=1664-3224

ABSTRACT=<p>Antigen cross-presentation, the process in which exogenous antigens are presented on MHC class I molecules, is crucial for the generation of effector CD8<sup>+</sup> T cell responses. Although multiple cell types are being described to be able to cross-present antigens, <italic>in vivo</italic> this task is mainly carried out by certain subsets of dendritic cells (DCs). Aspects such as the internalization route, the pathway of endocytic trafficking, and the simultaneous activation through pattern-recognition receptors have a determining influence in how antigens are handled for cross-presentation by DCs. In this review, we will summarize new insights in factors that affect antigen cross-presentation of human DC subsets, and we will discuss the possibilities to exploit antigen cross-presentation for immunotherapy against cancer.</p>