AUTHOR=Avalos Ana M., Ploegh Hidde 

TITLE=Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells

JOURNAL=Frontiers in Immunology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00092

DOI=10.3389/fimmu.2014.00092

ISSN=1664-3224

ABSTRACT=<p>B cells are efficient antigen-presenting cells (APCs), relying on antigen uptake through the B cell receptor (BCR). The mechanism of antigen recognition remains a topic of debate; while the prevalent view holds that antigens need to be multivalent for BCR activation, monovalent antigens can also initiate B cell responses. In this review, we describe the steps required for antigen uptake, processing, and loading of peptides onto MHC Class II compartments in B cells for efficient presentation to CD4 T cells, with a special focus in the initial steps of BCR recognition of antigen.</p>