AUTHOR=Palombo Fabio , Focaccetti Chiara , Barnaba Vincenzo TITLE=Therapeutic Implications of Immunogenic Cell Death in Human Cancer JOURNAL=Frontiers in Immunology VOLUME=4 YEAR=2014 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00503 DOI=10.3389/fimmu.2013.00503 ISSN=1664-3224 ABSTRACT=

Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.