AUTHOR=Garlanda Cecilia , Riva Federica , Bonavita Eduardo , Gentile Stefania , Mantovani Alberto 

TITLE=Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

JOURNAL=Frontiers in Immunology

VOLUME=4

YEAR=2013

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00180

DOI=10.3389/fimmu.2013.00180

ISSN=1664-3224

ABSTRACT=<p>Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and “receptors” with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.</p>