AUTHOR=Fehres Cynthia M., Garcia-Vallejo Juan J. , Unger Wendy W., Van Kooyk Yvette TITLE=Skin-Resident Antigen-Presenting Cells: Instruction Manual for Vaccine Development JOURNAL=Frontiers in Immunology VOLUME=4 YEAR=2013 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00157 DOI=10.3389/fimmu.2013.00157 ISSN=1664-3224 ABSTRACT=
The induction of antigen-specific effector T cells is driven by proper antigen presentation and co-stimulation by dendritic cells (DCs). For this reason strategies have been developed to instruct DCs for the induction of CD4+ and CD8+ T cell responses. Since DCs are localized, amongst other locations, in peripheral tissues such as the skin, new vaccines are aiming at targeting antigens to DCs