AUTHOR=Narayana Moorthy Anandi , Narasaraju Teluguakula , Rai Prashant , Perumalsamy Ramar , Tan K B., Wang Shi , Engelward Bevin , Chow Vincent T. TITLE=In vivo and in vitro studies on the roles of neutrophil extracellular traps during secondary pneumococcal pneumonia after primary pulmonary influenza infection JOURNAL=Frontiers in Immunology VOLUME=Volume 4 - 2013 YEAR=2013 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00056 DOI=10.3389/fimmu.2013.00056 ISSN=1664-3224 ABSTRACT=
Seasonal influenza virus infections may lead to debilitating disease, and account for significant fatalities annually worldwide. Most of these deaths are attributed to the complications of secondary bacterial pneumonia. Evidence is accumulating to support the notion that neutrophil extracellular traps (NETs) harbor several antibacterial proteins, and trap and kill bacteria. We have previously demonstrated the induction of NETs that contribute to lung tissue injury in severe influenza pneumonia. However, the role of these NETs in secondary bacterial pneumonia is unclear. In this study, we explored whether NETs induced during pulmonary influenza infection have functional significance against infections with