AUTHOR=Slyker Jennifer A., Lohman-Payne Barbara L., John-Stewart Grace , Dong Tao , Mbori-Ngacha Dorothy , Tapia Kenneth , Atzberger Ann , Taylor Stephen , Rowland-Jones Sarah , Blish Catherine A. TITLE=The impact of HIV-1 infection and exposure on natural killer (NK) cell phenotype in Kenyan infants during the first year of life JOURNAL=Frontiers in Immunology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00399 DOI=10.3389/fimmu.2012.00399 ISSN=1664-3224 ABSTRACT=
Natural killer (NK) cells play an important role in the containment of HIV replication during primary infection, though their functions are impaired during chronic HIV infection. Infants experience more rapid HIV disease progression than adults, but contributions of infant NK cells to containing HIV infection are unknown. The aim of this study was to determine the impact of HIV infection on infant NK cell phenotype by evaluating samples and data from a cohort study of women and their infants, conducted in Nairobi, Kenya between 1999 and 2003. The percentage and phenotype of NK cells was evaluated longitudinally by multi-parameter flow cytometry over the first year of life in HIV-infected (HIV+, = 16), HIV-exposed uninfected (HIV-EU,