AUTHOR=Sagoo Pervinder , Lombardi Giovanna , Lechler Robert I. TITLE=Relevance of regulatory T cell promotion of donor-specific tolerance in solid organ transplantation JOURNAL=Frontiers in Immunology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00184 DOI=10.3389/fimmu.2012.00184 ISSN=1664-3224 ABSTRACT=
Current clinical strategies to control the alloimmune response after transplantation do not fully prevent induction of the immunological processes which lead to acute and chronic immune-mediated graft rejection, and as such the survival of a solid organ allograft is limited. Experimental research on naturally occurring CD4+CD25highFoxP3+ Regulatory T cells (Tregs) has indicated their potential to establish stable long-term graft acceptance, with the promise of providing a more effective therapy for transplant recipients. Current approaches for clinical use are based on the infusion of freshly isolated or