AUTHOR=Rossy Jeremie , Williamson David J., Gaus Katharina 

TITLE=How does the kinase Lck phosphorylate the T cell receptor? Spatial organization as a regulatory mechanism

JOURNAL=Frontiers in Immunology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00167

DOI=10.3389/fimmu.2012.00167

ISSN=1664-3224

ABSTRACT=<p>T cell signaling begins with the ligation of the T cell antigen receptor (TCR) by a cognate peptide and the phosphorylation of the receptor’s immunoreceptor tyrosine-based activation motif domains by the kinase Lck. However, the canonical receptor model is insufficient to explain how the constitutively active kinase Lck can discriminate between non-ligated and ligated TCRs. Here, we discuss the factors that are thought to regulate the spatial distribution of the TCR and Lck, and therefore critically influence TCR signaling initiation.</p>