AUTHOR=Mastelic Beatris , Freitas do Rosario Ana Paula , Veldhoen Marc , Renauld Jean-Christophe , Jarra William , Sponaas Anne-Marit , Roetynck Sophie , Stockinger Brigitta , Langhorne Jean TITLE=IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection JOURNAL=Frontiers in Immunology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00085 DOI=10.3389/fimmu.2012.00085 ISSN=1664-3224 ABSTRACT=
The host response following malaria infection depends on a fine balance between levels of pro-inflammatory and anti-inflammatory mediators resulting in the resolution of the infection or immune-mediated pathology. Whilst other components of the innate immune system contribute to the pro-inflammatory milieu, T cells play a major role. For blood-stage malaria, CD4+ and γδ T cells are major producers of the IFN-γ that controls parasitemia, however, a role for TH17 cells secreting IL-17A and other cytokines, including IL-17F and IL-22 has not yet been investigated in malaria. TH17 cells have been shown to play a role in some protozoan infections, but they also are a source of pro-inflammatory cytokines known to be involved in protection or pathogenicity of infections. In the present study, we have investigated whether IL-17A and IL-22 are induced during a