AUTHOR=van der Merwe Philip Anton , Zhang Hao , Cordoba Shaun-Paul TITLE=Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane? JOURNAL=Frontiers in Immunology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00029 DOI=10.3389/fimmu.2012.00029 ISSN=1664-3224 ABSTRACT=

Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signaling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in more physiological systems have confirmed membrane association but raised questions as to its function.