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ORIGINAL RESEARCH article
Front. Hum. Neurosci.
Sec. Brain Imaging and Stimulation
Volume 19 - 2025 | doi: 10.3389/fnhum.2025.1508526
This article is part of the Research TopicPrevention of and early intervention for behavioral health disorders in people with epilepsyView all 4 articles
Smoking and Epilepsy in National Health Interview Survey: A Cross-sectional Study
Provisionally accepted- 1Sun Yat-sen University, Guangzhou, China
- 2Karolinska Institutet (KI), Solna, Stockholm, Sweden
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Objective: This study aimed to examine the association between smoking and epilepsy in a nationwide cross-sectional analysis of US adults.Methods: Data from the National Health Interview Survey (NHIS) conducted between 2021 and 2022 were utilized, encompassing 57,088 participants aged 18-85 years with documented tobacco usage and self-reported epilepsy. Logistic regression models were employed to evaluate the relationship between smoking and epilepsy. The assessment of tobacco usage encompassed smoking status, cigarette smoking, pipe-filled tobacco smoking, and smokeless tobacco usage.Results: The overall prevalence of self-reported epilepsy in the sample was 1.76%, with smokers constituting 46.03% of cases. Individuals with epilepsy exhibited higher smoking rates compared to those without epilepsy. In the multivariate logistic regression model, smoking demonstrated a significant association with self-reported epilepsy (OR = 1.26, 95% CI: 1.07–1.47, P=0.005). Subsequent stratified analyses showed consistent associations between smoking and self-reported epilepsy in all sex and ethnic subgroups.Conclusions: Our findings suggest that smoking is independently associated with self-reported epilepsy among US adults. Further investigation into the biological mechanisms underlying this association is warranted, contingent upon the validation of these results in an external population.
Keywords: Epilepsy, Smoke, tabacco, NHIS, Cross-sectional study
Received: 09 Oct 2024; Accepted: 16 Apr 2025.
Copyright: © 2025 Huang, Liu, Zhao, Ji and Zhan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yiqiang Zhan, Karolinska Institutet (KI), Solna, 171 77, Stockholm, Sweden
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