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REVIEW article
Front. Hum. Neurosci.
Sec. Brain Health and Clinical Neuroscience
Volume 19 - 2025 |
doi: 10.3389/fnhum.2025.1471433
Potential Common Targets of Music Therapy Intervention in Neuropsychiatric Disorders: The Prefrontal Cortex-hippocampus -amygdala Circuit(A Review)
Provisionally accepted
Yuqin Dan 1
Ying Xiong 2*
Danghan Xu 3 Yuqi Wang 1*
Yin Meng 4 Pengwei Sun 5*
Yi Ding 6 Ziyun Feng 6*
Peng Sun 7* Weili Xia 8*
Gongchang Yu 4,5,8,9*
Li Li 6*- 1 Rehabilitation Medicine School, Shandong University of Traditional Chinese Medicine, Jinan, China
- 2 chool of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
- 3 Rehabilitation center,, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
- 4 Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong Province, China
- 5 School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 6 Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 7 Institute for Literature and Culture of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
- 8 Shandong Provincial Mental Health Center, Shandong, China
- 9 Shandong First Medical University, Tai'an, Shandong, China
As life becomes more stressful, neurological disorders, psychiatric disorders, and comorbidities of the two are becoming more and more of a concern. Multiple neuropsychiatric disorders share the same mental and somatic dysfunction and may involve common brain circuits and mechanistic targets. Music therapy, as an art form with proven efficacy, low cost and few side effects, is promoted for use in interventions for neuropsychiatric disorders. This may be closely related to the release of signalling molecules such as monoamine neurotransmitters, the glutamatergic system, the gut-microbiota-brain axis, pro-inflammatory cytokines and the endogenous opioid peptide system. However, fewer studies have mentioned the main targets of music to promote functional changes in brain regions. Therefore, this paper is a review of the mechanisms by which music therapy interacts with the prefrontal cortex-hippocampus-amygdala circuit through the aforementioned molecules. It is also hypothesised that glial cells, mitochondria and microRNAs are microscopic targets for musical intervention in neuropsychiatric disorders. The aim is to give new ideas for future research into the biological mechanisms of music therapy intervention in neuropsychiatric disorders.
Keywords: neuropsychiatric disorders1, music therapy2, the prefrontal cortex-hippocampus -amygdala circuit3, potential mechanisms4, common targets5
Received: 12 Aug 2024; Accepted: 17 Jan 2025.
Copyright: © 2025 Dan, Xiong, Xu, Wang, Meng, Sun, Ding, Feng, Sun, Xia, Yu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Xiong, chool of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
Yuqi Wang, Rehabilitation Medicine School, Shandong University of Traditional Chinese Medicine, Jinan, China
Pengwei Sun, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, China
Ziyun Feng, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250001, Shandong Province, China
Peng Sun, Institute for Literature and Culture of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
Weili Xia, Shandong Provincial Mental Health Center, Shandong, China
Gongchang Yu, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, 250062, Shandong Province, China
Li Li, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250001, Shandong Province, China
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