Skip to main content

BRIEF RESEARCH REPORT article

Front. Hum. Neurosci.
Sec. Brain Imaging and Stimulation
Volume 18 - 2024 | doi: 10.3389/fnhum.2024.1501310

Neuronal basis of high frequency fMRI fluctuation: direct evidence from simultaneous recording

Provisionally accepted
Yang Qiao Yang Qiao 1Harry Hanbing Lu Harry Hanbing Lu 2Yihong Yang Yihong Yang 2*Yu-Feng Zang Yu-Feng Zang 1*
  • 1 Hangzhou Normal University, Hangzhou, China
  • 2 National Institute on Drug Abuse (NIH), Bethesda, Maryland, United States

The final, formatted version of the article will be published soon.

    Resting-state functional magnetic resonance imaging (RS-fMRI) has been extensively utilized for noninvasive investigation of human brain activity. While studies employing simultaneous recordings of fMRI and electrophysiology have established a connection between the low-frequency fluctuation (< 0.1 Hz) observed in RS-fMRI and the local field potential (LFP), it remains unclear whether the RS-fMRI signal exhibits frequency-dependent modulation, which is a well-documented phenomenon in LFP. The present study concurrently recorded resting-state functional magnetic resonance imaging (RS-fMRI) and local field potentials (LFP) in the striatum of 8 rats before and after a pharmacological manipulation. We observed a highly similar frequency-dependent pattern of amplitude changes in both RS-fMRI and LFP following the manipulation, specifically an increase in high-frequency band amplitudes accompanied by a decrease in low-frequency band amplitudes. These findings provide direct evidence that the enhanced high-frequency fluctuations and reduced lowfrequency fluctuations observed in RS-fMRI may reflect heightened neuronal activity.

    Keywords: resting state fMRI, local field potential, Simultaneous recording, Drug manipulation, Frequency-dependent pattern

    Received: 24 Sep 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Qiao, Lu, Yang and Zang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yihong Yang, National Institute on Drug Abuse (NIH), Bethesda, 20892, Maryland, United States
    Yu-Feng Zang, Hangzhou Normal University, Hangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.