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ORIGINAL RESEARCH article

Front. Hum. Neurosci.
Sec. Cognitive Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnhum.2024.1474148

Vitamin D and focal brain atrophy in Parkinson's disease with non-dementia patients: a voxel-based morphometric study

Provisionally accepted
Yingying Xu Yingying Xu Erlei Wang Erlei Wang *Qilin Zhang Qilin Zhang *Jing Liu Jing Liu *Weifeng Luo Weifeng Luo *
  • Second Affiliated Hospital of Soochow University, Suzhou, China

The final, formatted version of the article will be published soon.

    The status of vitamin D has been proposed to have an impact on cognition.Gray matter volume (GMV) is a potential marker of cognitive function. We investigated whether lower serum 25-hydroxyvitamin D level was associated with reduced cerebral GMV in Parkinson's disease with non-dementia (PDND) patients.Methods: Baseline neuropsychiatric performance and serum 25-hydroxyvitamin D levels were examined in 24 PDND patients and 24 healthy controls (HCs). A set of cognitive scales were used to evaluate the cognition. Voxel-based morphometry (VBM) was performed to calculate each PDND patient's GMV, based on structural magnetic resonance imaging data.Associations between serum 25-hydroxyvitamin D levels, cognition, and GMV were evaluated.: The serum 25-hydroxyvitamin D levels of the PDND group were significantly lower than those of the HC group. The simple linear regression analyses between serum 25-hydroxyvitamin D levels and the scores of subtests that analyzed cognitive function showed that serum 25-hydroxyvitamin D levels were negatively correlated with Trail Making Test-A scores and positively correlated with Symbol Digit Modalities Test and Auditory Verbal Learning Test scores. Multiple regression analyses revealed a positive correlation between the right fusiform gyrus GMV and serum 25-hydroxyvitamin D levels. Conclusions: We hypothesized that the lower serum 25-hydroxyvitamin D level in patients with PDND might affect auditory word learning and spatial cognition ability by reducing the gray matter volume of the right fusiform gyrus, thereby leading to deterioration of semantic understanding and memory function.

    Keywords: Parkinson's disease, Vitamin D, Cognition, voxel-based morphometry, Gray matter volume 3 / 18

    Received: 01 Aug 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Xu, Wang, Zhang, Liu and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Erlei Wang, Second Affiliated Hospital of Soochow University, Suzhou, China
    Qilin Zhang, Second Affiliated Hospital of Soochow University, Suzhou, China
    Jing Liu, Second Affiliated Hospital of Soochow University, Suzhou, China
    Weifeng Luo, Second Affiliated Hospital of Soochow University, Suzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.