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CASE REPORT article

Front. Hum. Neurosci.
Sec. Motor Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnhum.2024.1464152

Case report: Levodopa challenge test is important in identifying dopamine-induced freezing of gait in patient with Parkinson's disease

Provisionally accepted
Shan-Shan Xu Shan-Shan Xu Shi-Guo Zhu Shi-Guo Zhu Cheng-Xiang Yuan Cheng-Xiang Yuan Guo-Ling Zeng Guo-Ling Zeng Xiao-Tian Li Xiao-Tian Li Rong-Pei Liu Rong-Pei Liu Shi-Shi Huang Shi-Shi Huang Xiong Zhang Xiong Zhang Jian-Yong Wang Jian-Yong Wang *
  • Wenzhou Medical University, Wenzhou, China

The final, formatted version of the article will be published soon.

    Introduction: Freezing of gait (FOG) is a disabling and heterogeneous symptom in patients with Parkinson’s disease (PD). Among them, dopamine-induced FOG is rare and difficult to identify. The treatment of dopamine-induced FOG is complex. Case presentation: We herein presented a case of PD patient who complicated with refractory FOG. It was identified as dopamine-induced FOG during levodopa challenge test. Her symptoms were alleviated after we reduced the total equivalent dosage of levodopa. Conclusion: Our report emphasizes the importance of levodopa challenge test in identifying different types of FOG, which is very important for further adjusting treatment.

    Keywords: Parkinson's disease, freezing of gait, levodopa challenge test, Dopamine-induced FOG, case report

    Received: 17 Jul 2024; Accepted: 26 Aug 2024.

    Copyright: © 2024 Xu, Zhu, Yuan, Zeng, Li, Liu, Huang, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jian-Yong Wang, Wenzhou Medical University, Wenzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.