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ORIGINAL RESEARCH article

Front. Hum. Neurosci.
Sec. Brain Imaging and Stimulation
Volume 18 - 2024 | doi: 10.3389/fnhum.2024.1463740
This article is part of the Research Topic Latest Advances in Neuroscience at the 9th Croatian Neuroscience Congress View all 13 articles

Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments

Provisionally accepted
Ines Strbacko Ines Strbacko 1,2Milan Radoš Milan Radoš 2Ivana Jurjevic Ivana Jurjevic 1,3Darko Orešković Darko Orešković 4Marijan Klarica Marijan Klarica 1,2*
  • 1 School of Medicine, University of Zagreb, Zagreb, Croatia
  • 2 Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
  • 3 Department of Neurology, University Hospital Centre Zagreb, Zagreb, Croatia
  • 4 Division of Molecular Biology, Rudjer Boskovic Institute, Zagreb, Croatia

The final, formatted version of the article will be published soon.

    Introduction: It is generally accepted that during body position changes from horizontal to vertical there is a short-lasting shift of a certain CSF volume from the cranium into the hydrostatically lower parts of the spinal space, which leads to transitory CSF pressure decrease to negative values.In order to test this, we performed MRI volumetry of cranial and spinal part of the CSF space in healthy volunteers of both genders (n=22) in three different body positions [horizontal (H); elevated head and upper body (H-UP) under an angle about 30° from the base; elevated lower body (B-UP) under an angle about 30° from the base].Results: Volumes of brain and spinal cord tissue did not change during body position changes. Significant CSF volume (ml) changes occur inside the spinal space in the tested body positions, primarily in the lumbosacral segment ( H-UP -38.1 ± 7.0; H -34.4 ± 6.5; B-UP -28.7 ± 6.5), while at the same time no significant CSF volume changes have been observed inside the cranium in two tested positions (H and B-UP) in which it was possible to measure intracranial CSF volume changes or if we sum up cervical and cranial CSF volumes in those positions.Observed results suggest that during the changes of body position CSF volume redistribution occurs, primarily inside the spinal and not the cranial space. This is in accordance with the new hypothesis by which spinal intradural space can significantly change its volume due to its elasticity, thus adjusting to the influence of gravity and pressure changes.

    Keywords: cranial CSF volume, spinal CSF volume, Body position, volume redistribution, segmentation, MR volumetry

    Received: 29 Jul 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 Strbacko, Radoš, Jurjevic, Orešković and Klarica. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Marijan Klarica, School of Medicine, University of Zagreb, Zagreb, Croatia

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