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REVIEW article

Front. Hum. Neurosci.
Sec. Cognitive Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnhum.2024.1448791
This article is part of the Research Topic Women in Cognitive Neuroscience: 2023 View all articles

Entorhinal cortex-hippocampal circuit connectivity in health and disease

Provisionally accepted
Melissa Hernández-Frausto Melissa Hernández-Frausto 1,2*Carmen Vivar Carmen Vivar 3*
  • 1 Neuroscience Institute, Langone Medical Center, New York University, New York, New York, United States
  • 2 Grossman School of Medicine, New York University, New York, New York, United States
  • 3 Other, Mexico City, México, Mexico

The final, formatted version of the article will be published soon.

    The entorhinal cortex (EC) and hippocampal (HC) connectivity is the main source of episodic memory formation and consolidation. The entorhinal-hippocampal (EC-HC) connection is classified as canonically glutamatergic and more recently has been characterized as a noncanonical GABAergic connection. Recent evidence shows that both EC and HC receives inputs from dopaminergic, cholinergic, and noradrenergic projections that modulates the mnemonic processes linked to the encoding and consolidation of memories. In the present review, we address the latest findings on the EC-HC connectivity and the role of neuromodulations during the mnemonic mechanisms of encoding and consolidation of memories and highlight the value of cross-species approach to unravel the underlying cellular mechanisms known. Furthermore, we discuss how EC-HC connectivity early neurodegeneration may contribute to the dysfunction of episodic memories observed in aging and Alzheimer's disease (AD). Lastly, we described how exercise may be a fundamental tool to prevent or decrease neurodegeneration.

    Keywords: Entorhinal Cortex, Hippocampus, Neuromodulation, episodic memory, Alzheimer's disease, Exercise, Aging

    Received: 13 Jun 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 Hernández-Frausto and Vivar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Melissa Hernández-Frausto, Neuroscience Institute, Langone Medical Center, New York University, New York, 10016, New York, United States
    Carmen Vivar, Other, Mexico City, México, Mexico

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.