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ORIGINAL RESEARCH article

Front. Hum. Neurosci.
Sec. Cognitive Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnhum.2024.1412572

Frequency-specific static and dynamic neural activity indices in children with different attention deficit hyperactivity disorder subtypes: a resting-state fMRI study

Provisionally accepted
Ran Chen Ran Chen 1Yun Jiao Yun Jiao 1,2*Jun-Sa Zhu Jun-Sa Zhu 1Xun-Heng Wang Xun-Heng Wang 3Mei-Ting Zhao Mei-Ting Zhao 1
  • 1 Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China, Nanjing, China
  • 2 Network Information Center, Zhongda Hospital, Medical School of Southeast University, Nanjing, China, Nanjing, China
  • 3 Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, Hangzhou, China, Hangzhou, China

The final, formatted version of the article will be published soon.

    Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood. Numerous resting-state functional magnetic resonance imaging (rs-fMRI) studies in ADHD have been performed using traditional lowfrequency bands (0.01-0.08 Hz). However, the neural activity patterns of frequency subbands in ADHD still require further investigation. The purpose of this study is to explore the frequency-dependent characteristics and neural activity patterns of ADHD subtypes. We selected the ADHD combined type (ADHD-C, N=25), ADHD inattentive type (ADHD-I, N=26) and typically developing (TD, N=28) children from the ADHD-200 Consortium. Based on the slow-5 band (0.01-0.027 Hz) and slow-4 band (0.027-0.073 Hz), we generated static and dynamic fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) maps for each participant. A flexible-factorial analysis of variance model was performed on static and temporal dynamic rs-fMRI measurements within two subbands.Results revealed that the orbital-frontal gyrus, precuneus, superior temporal gyrus and angular gyrus were found to have obvious frequency band and group interaction effects. The intrinsic neural activity differences among three groups were more prominent in the slow-5 frequency band compared to the slow-4 band. In addition, the indices of significant interaction regions showed correlations with the progression of the disease and the features in slow-5 showed an advantageous diagnostic performance compared with those in slow-4. The results suggested the intrinsic neural activities of ADHD subtypes were frequency-dependent. The frequencyspecific analysis of static and dynamic brain activity may provide a deeper understanding of neurophysiological dysfunction patterns in ADHD subtypes and provide supplementary information for assessing ADHD subtypes.

    Keywords: Attention Deficit Hyperactivity Disorder, resting-state functional fMRI, ADHD subtype, frequency band, temporal dynamics

    Received: 05 Apr 2024; Accepted: 17 Jul 2024.

    Copyright: © 2024 Chen, Jiao, Zhu, Wang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yun Jiao, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China, Nanjing, China

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